苏州方舟基因药业有限公司
 
   
 

 

 
     

Most Recent Publications:

  1. Xin Guan, et al. Scalable generation of megakaryocytes and platelets from small-molecule/cytokine expanded cord blood CD34+ cells in a bottle turning culture system. 2017(In preparation)
  2. Meng Qin, et al. Evaluation of ex vivo produced endothelial progenitor cells for autologous transplantation in primates.Stem Cell Research & Therapy. 2018, 9:14
  3. Huihui Wang, et al. Cryopreserved human CD34+ cell products retain in vitro expansion potential and clonogenic capacity after short-time cryostorage. 2017(In preparation)
  4. Wang YX, Du YS, Zhang YY, Chen X, Gu HC, Yang RC, Jiang YP,Ren ZH. Identification of Rare Inherited and De Novo SNPs in Chinese Multiplex Families with ASD. 2017(In preparation)
  5. Du YS, Wang YX, Zhang YY, Gu HC, Li H, Jiang YP, Ren ZH. Expanded Targeted Next-generation Sequencing for Sporadic Autism Spectrum Disorder in Chinese cohorts.2017 (In preparation)
  6. Hanlu Wang, Meng Qin, Zhihua Ren, Irvin S.Y. Chen and Yongping Jiang. A Synthesized RNA Aptamer Targeting and Inhibiting Non-Small Cell Lung Cancer. 2017(In preparation)
  7. Hanlu Wang, Yibang Zhang, Haiping Yang, Zhihua Ren, Rihe Liu, Xinxin Ding, Wei Dai and Yongping Jiang.In Vivo SELEX of an Inhibitory NSCLC-Specific RNA Aptamer from PEGylated RNA Library. Molecular Therapy- Nucleic Acids. 2018,10:187-198.
  8. Xiao Chen, et al. Targeted gene panel sequencing in a large cohort of children with sporadic non-syndromic congenital heart disease in China. 2017(submitted)
  9. Lan Wang, Xin Guan, Huihui Wang, Bin Shen, Yu Zhang, Zhihua Ren, Yupo Ma, Xinxin Ding, Yongping Jiang. A small-molecule combination enhances hematopoietic stem cell proliferation via inhibition of differentiation. Stem Cell Research & Therapy. 2017, 8: 169
  10. Yu Zhang,Chen Wang, Lan Wang, Jing Tian, Bin Shen, Xin Guan, Zhihua Ren, Xinxin Ding, Yupo Ma, Wei Dai, Yongping Jiang. Large-scale Ex Vivo Generation of Human Red Blood Cells from Cord Blood CD34+ Cells, Stem cells Translational medicine, 2017. doi: 10.1002/sctm.17-0057.
  11. Zhenwang Jie, Bin Shen, Yu Zhang, Chen Wang, Xin Guan, Zhihua Ren, Xinxin Ding, Wei Dai, Yongping Jiang. Large-Scale Ex vivo Generation of Human Neutrophils from Cord Blood CD34+ Cells, PLos One, 2017, 12(7):e0180832.
  12. Yu Zhang, Bin Shen, Xin Guan, Meng Qin, Zhihua Ren, Xinxin Ding, Yupo Ma, Wei Dai, Yongping Jiang. Effective Expansion of CD34+ Hematopoietic Stem Cells with Long-term Potential of Repopulation and Multi-lineage Differentiation, Stem cells Translational medicine, 2017 (submitted revised version)
  13. Meng Qin, Xin Guan, Huihui Wang, Yu Zhang, Bin Shen, Qingyu Zhang, Wei Dai, Yupo Ma, Yongping Jiang*. An Effective Ex Vivo Approach for Inducing Endothelial Progenitor Cells from Umbilical Cord Blood CD34+ Cells. Stem Cell Res Ther. 2017, 8(1): 25
  14. Xin Guan, Meng Qin, Yu Zhang, Yanan Wang, Bin Shen, Zhihua Ren, Xinxin Ding, Wei Dai*, Yongping Jiang*. Safety and Efficacy of Megakaryocytes Induced From Hematopoietic Stem Cells in Murine and Nonhuman Primate Models. Stem Cells Transl Med. 2017, 6(3): 897-909
  15. Bin Shen, Yu Zhang, Wei Dai, Yupo Ma*, Yongping Jiang. Ex Vivo Expansion of Nonhuman Primate CD34+ Cells by Stem Cell Factor Sall4B. Stem Cell Res Ther. 2016, 7:152
  16. Ren Z, Zhang Y, Zhang Y, Jiang W, Dai W, Ding X, Jiang Y. Influence of IL-3 functional fragment on cord blood stem cell ex vivo expansion and differentiation. Stem Cell Investig. 2016, 3: 6.
  17. Shen B, Jiang W, Fan J, Dai W, Ding X, Jiang Y. Residues 39-56 of Stem Cell Factor Protein Sequence Are Capable of Stimulating the Expansion of Cord Blood CD34+ Cells. PLoS One. 2015, 10(10): e141485.
  18. Shi K, Jie Z, Chu C, Zhang Q, Ding X, Jiang Y. A Novel Recombinant Human Granulocyte Colony-Stimulating Factor (G-CSFa) Enhances Peripheral Platelet Recovery in Mice Exposed to adiotherapy and Has No Immunogenicity in Rats. Journal of Carcinogenesis & Mutagenesis. 2014, 5(2): 162.
  19. Yuan M, Wang Y, Ren Z, Dai W, Jiang Y. Transactivating Target Gene Expression by Recombinant SALL4B: A Pluripotent Stem Cell Marker. J Stem Cell Res Ther. 2014, 4: 203.
  20. Ren Z, Wang Y, Jiang W, Dai W, Jiang Y. Anti-Tumor Effect of a Novel Soluble Recombinant Human Endostatin: Administered as a Single Agent orin Combination with Chemotherapy Agents in Mouse Tumor Models. PLoS ONE. 2014, 9(9): e107823.
  21. Xu S, Ren Z, Wang Y, Ding X, Jiang Y. Preferential Expression of Cytochrome P450 CYP2R1 but not CYP1B1 in Human Cord Blood Hematopoietic Stem and Progenitor Cells. Acta Pharmaceutica Sinica B. 2014. doi:10.1016/j.apsb.2014.10.003
  22. Wu M, Yang F, Ren Z, Jiang Y, Ma Y, Chen Y, Dai W. Identification of the nuclear localization signal of SALL4B, a stem cell transcription factor. Cell Cycle. 2014, 13(9).
  23. Yao Y, Lu Y, Chen W C, Jiang Y, Cheng T, Ma Y, Lu L, Dai W. Cobalt and nickel stabilize stem cell transcription factor OCT4 through modulating its sumoylation and ubiquitination. PLoS One. 2014, 9(1): e86620.
  24. Liao W, Aguila J R, Yao Y, Yang J, Zieve G, Jiang Y, Avila C, Senzel L, Lai R, Xu D, Dai W, Ma Y. Enhancing bone marrow regeneration by SALL4 protein. J Hematol Oncol. 2013, 6: 84.
  25. Zhang Y, Dai W, Jiang Y. Prokaryotic expression of recombinant human interleukin 3 and its effects on extracorporeal proliferation of cord blood hematopoietic stem cells. Journal of Clinical Medicine in Practice. 2013, 17(5): 8-12.
  26. Tian J, Jiang Y. Study progress of cytokines' effect on ex vivo expansion of human hematopoietic stem cells. BME & Clin Med. 2013, 17(5).
  27. Ren Z, Jiang Y. Umbilical Cord Blood Hematopoietic Stem Cell Expansion Ex Vivo. Journal of Blood Disorders & Transfusion. 2013, S3: 4.
  28. Lu Y, Xu D, Zhou J, Ma Y, Jiang Y, Zeng W, Dai W. Differential responses to genotoxic agents between induced pluripotent stem cells and tumor cell lines. J Hematol Oncol. 2013, 6(1): 71.
  29. Liu L, Souto J, Liao W, Jiang Y, Li Y, Nishinakamura R, Huang S, Rosengart T, Yang V W, Schuster M, Ma Y, Yang J. Histone Lysine-specific Demethylase 1 (LSD1) Protein Is Involved in Sal-like Protein 4 (SALL4)-mediated Transcriptional Repression in Hematopoietic Stem Cells. J Biol Chem. 2013, 288(48): 34719-34728.
  30. Yang J, Corsello T R, Ma Y. Stem cell gene SALL4 suppresses transcription through recruitment of DNA methyltransferases. J Biol Chem. 2012, 287(3): 1996-2005.
  31. Yang F, Yao Y, Jiang Y, Lu L, Ma Y, Dai W. Sumoylation is important for stability, subcellular localization, and transcriptional activity of SALL4, an essential stem cell transcription factor. J Biol Chem. 2012, 287(46): 38600-38608.
  32. Xu D, Wang Q, Jiang Y, Zhang Y, Vega-Saenzdemiera E, Osman I, Dai W. Roles of Polo-like kinase 3 in suppressing tumor angiogenesis. Exp Hematol Oncol. 2012, 1(1): 5.
  33. Song S, Jiang W, Jiang Y. Large-scale production, refolding, and purification of a novel recombinant human granulocyte colony stimulating factor. Chinese Journal of Biomedical Engineering. 2012, 31(04): 552-557.
  34. Fan J, Ding X, Jiang Y. A novel monoclonal antibody of human stem cell factor inhibits umbilical cord blood stem cell ex vivo expansion. J Hematol Oncol. 2012, 5: 73.
  35. Fan J, Ding X, Jiang Y. Expression, refolding, and purification of recombinant human stem cell factor and determination of its effect on ex vivo expansion of cord blood. J of Clin Med in Practice. 2012, 16: 20-23.
  36. Fan J, Ding X, Jiang Y. Pre-clinical acute toxicity and sub-acute toxicity study on a novel recombinant human granulocyte-colony stimulating factor a (rhG-CSFa). Fudan University Journal of Medical Sciences. 2012, 1: 8.
  37. Xu D, O T M, Shartava A, Fowles T C, Yang J, Fink L M, Ward D C, Mihm M C, Waner M, Ma Y. Isolation, characterization, and in vitro propagation of infantile hemangioma stem cells and an in vivo mouse model. J Hematol Oncol. 2011, 4: 54.
  38. Xia F, Zhang Q Y, Jiang Y P. Chronic toxicity of a novel recombinant human granulocyte colony-stimulating factor in rats. Chin Med Sci J. 2011, 26(1): 20-27.
  39. Jiang Y, Jiang W, Qiu Y, Dai W. Effect of a structurally modified human granulocyte colony stimulating factor, G-CSFa, on leukopenia in mice and monkeys. J Hematol Oncol. 2011, 4: 28.
  40. Zhao L, Jiang Y. Optimization of refolding and purification of a novel recombinant human endostatin from E.coli. Basic Clin Med. 2010, 30: 492-495.
  41. Liu X X, Jiang Y P. Pharmacokinetic study of a novel recombinant human granulocyte colony-stimulating factor in rats. Chin Med Sci J. 2010, 25(1): 13-19.
  42. Zhao L, Sun J, Jiang Y. Application and development of genetic engineering technology in biopharmaceutics. Basic Clin Med. 2009, 29: 996-998.
  43. Jiang Y, Jiang W, Dai W. Effect of a mutant human granulocyte colony-stimulating factor, G-CSFC17-M, on leukopenia in mice and monkeys. Proc Amer Assoc Cancer Res. 2009: 461185-461186.

 

Additional Publications:

  1. Shen B, Jiang W, Fan J, Dai W, Ding X, Jiang Y. Residues 39-56 of Stem Cell Factor Protein Sequence Are Capable of Stimulating the Expansion of Cord Blood CD34+ Cells. PLoS One. 2015, 10(10): e141485.
  2. Valencia C A, Zou J, Liu R. In vitro selection of proteins with desired characteristics using mRNA-display. Methods. 2013, 60(1): 55-69.
  3. Fu C, Zheng X, Jiang Y, Liu Y, Xu P, Zeng Z, Liu R, Zhao Y. A universal and multiplex kinase assay using gamma-[(18)O(4)]-ATP. Chem Commun (Camb). 2013, 49(27): 2795-2797.
  4. Friedman A D, Claypool S E, Liu R. The smart targeting of nanoparticles. Curr Pharm Des. 2013, 19(35): 6315-6329.
  5. Li Y, Gong Y, Li L, Abdolmaleky H M, Zhou J R. Bioactive tanshinone I inhibits the growth of lung cancer in part via downregulation of Aurora A function. Mol Carcinog. 2013, 52(7): 535-543.
  6. Yamada H Y, Yao Y, Wang X, Zhang Y, Huang Y, Dai W, Rao C V. Haploinsufficiency of SGO1 results in deregulated centrosome dynamics, enhanced chromosomal instability and colon tumorigenesis. Cell Cycle. 2012, 11(3): 479-488.
  7. Yang F, Hu L, Chen C, Yu J, O'Connell C B, Khodjakov A, Pagano M, Dai W. BubR1 is modified by sumoylation during mitotic progression. J Biol Chem. 2012, 287(7): 4875-4882.
  8. Yang F, Huang Y, Dai W. Sumoylated BubR1 plays an important role in chromosome segregation and mitotic timing. Cell Cycle. 2012, 11(4): 797-806.
  9. Yao Y, Dai W. Mitotic checkpoint control and chromatin remodeling. Front Biosci (Landmark Ed). 2012, 17: 976-983.
  10. Yao Y, Dai W. Shugoshins function as a guardian for chromosomal stability in nuclear division. Cell Cycle. 2012, 11(14): 2631-2642.
  11. Bardowell S A, Ding X, Parker R S. Disruption of P450-mediated vitamin E hydroxylase activities alters vitamin E status in tocopherol supplemented mice and reveals extra-hepatic vitamin E metabolism. J Lipid Res. 2012, 53(12): 2667-2676.
  12. Fang C, Bolivar V J, Gu J, Yang W, Zeitlin S O, Ding X. Neurobehavioral abnormalities in a brain-specific NADPH-cytochrome P450 reductase knockout mouse model. Neuroscience. 2012, 218: 170-180.
  13. Lin Y, Yao Y, Liu S, Wang L, Moorthy B, Xiong D, Cheng T, Ding X, Gu J. Role of mammary epithelial and stromal P450 enzymes in the clearance and metabolic activation of 7,12-dimethylbenz(a)anthracene in mice. Toxicol Lett. 2012, 212(2): 97-105.
  14. D'Agostino J, Ding X, Zhang P, Jia K, Fang C, Zhu Y, Spink D C, Zhang Q Y. Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes. J Biol Chem. 2012, 287(21): 17777-17788.
  15. Wei Y, Wu H, Li L, Liu Z, Zhou X, Zhang Q Y, Weng Y, D'Agostino J, Ling G, Zhang X, Kluetzman K, Yao Y, Ding X. Generation and characterization of a CYP2A13/2B6/2F1-transgenic mouse model. Drug Metab Dispos. 2012, 40(6): 1144-1150.
  16. Bai Y, Yang J, Zhou X, Ding X, Eisele L E, Bai G. Mycobacterium tuberculosis Rv3586 (DacA) is a diadenylate cyclase that converts ATP or ADP into c-di-AMP. PLoS One. 2012, 7(4): e35206.
  17. Zhou X, D'Agostino J, Xie F, Ding X. Role of CYP2A5 in the bioactivation of the lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in mice. J Pharmacol Exp Ther. 2012, 341(1): 233-241.
  18. Zhou X, D'Agostino J, Li L, Moore C D, Yost G S, Ding X. Respective roles of CYP2A5 and CYP2F2 in the bioactivation of 3-methylindole in mouse olfactory mucosa and lung: studies using Cyp2a5-null and Cyp2f2-null mouse models. Drug Metab Dispos. 2012, 40(4): 642-647.
  19. Court M H, Zhang X, Ding X, Yee K K, Hesse L M, Finel M. Quantitative distribution of mRNAs encoding the 19 human UDP-glucuronosyltransferase enzymes in 26 adult and 3 fetal tissues. Xenobiotica. 2012, 42(3): 266-277.
  20. Wang R, Cotten S W, Liu R. mRNA display using covalent coupling of mRNA to translated proteins. Methods Mol Biol. 2012, 805: 87-100.
  21. Cotten S W, Zou J, Wang R, Huang B C, Liu R. mRNA display-based selections using synthetic peptide and natural protein libraries. Methods Mol Biol. 2012, 805: 287-297.
  22. Benhabbour S R, Luft J C, Kim D, Jain A, Wadhwa S, Parrott M C, Liu R, DeSimone J M, Mumper R J. In vitro and in vivo assessment of targeting lipid-based nanoparticles to the epidermal growth factor-receptor (EGFR) using a novel Heptameric ZEGFR domain. J Control Release. 2012, 158(1): 63-71.
  23. Kim D, Yan Y, Valencia C A, Liu R. Heptameric targeting ligands against EGFR and HER2 with high stability and avidity. PLoS One. 2012, 7(8): e43077.
  24. Ni F, Gong Y, Li L, Abdolmaleky H M, Zhou J R. Flavonoid ampelopsin inhibits the growth and metastasis of prostate cancer in vitro and in mice. PLoS One. 2012, 7(6): e38802.
  25. Gong Y, Li Y, Abdolmaleky H M, Li L, Zhou J R. Tanshinones inhibit the growth of breast cancer cells through epigenetic modification of Aurora A expression and function. PLoS One. 2012, 7(4): e33656.
  26. Nagel J M, Brinkoetter M, Magkos F, Liu X, Chamberland J P, Shah S, Zhou J, Blackburn G, Mantzoros C S. Dietary walnuts inhibit colorectal cancer growth in mice by suppressing angiogenesis. Nutrition. 2012, 28(1): 67-75.
  27. Zhang Y W, Yan D L, Wang W, Zhao H W, Lu X, Wu J Z, Zhou J R. Knockdown of insulin-like growth factor I receptor inhibits the growth and enhances chemo-sensitivity of liver cancer cells. Curr Cancer Drug Targets. 2012, 12(1): 74-84.
  28. Gao J, Wang J, Wang Y, Dai W, Lu L. Regulation of Pax6 by CTCF during induction of mouse ES cell differentiation. PLoS One. 2011, 6(6): e20954.
  29. Hu L, Liu X, Chervona Y, Yang F, Tang M S, Darzynkiewicz Z, Dai W. Chromium induces chromosomal instability, which is partly due to deregulation of BubR1 and Emi1, two APC/C inhibitors. Cell Cycle. 2011, 10(14): 2373-2379.
  30. Wang L, Dai W, Lu L. Hyperosmotic stress-induced corneal epithelial cell death through activation of Polo-like kinase 3 and c-Jun. Invest Ophthalmol Vis Sci. 2011, 52(6): 3200-3206.
  31. Wang L, Payton R, Dai W, Lu L. Hyperosmotic stress-induced ATF-2 activation through Polo-like kinase 3 in human corneal epithelial cells. J Biol Chem. 2011, 286(3): 1951-1958.
  32. Xu D, Dai W. The function of mammalian Polo-like kinase 1 in microtubule nucleation. Proc Natl Acad Sci U S A. 2011, 108(28): 11301-11302.
  33. Li L, Wei Y, Van Winkle L, Zhang Q Y, Zhou X, Hu J, Xie F, Kluetzman K, Ding X. Generation and characterization of a Cyp2f2-null mouse and studies on the role of CYP2F2 in naphthalene-induced toxicity in the lung and nasal olfactory mucosa. J Pharmacol Exp Ther. 2011, 339(1): 62-71.
  34. Hollander M C, Zhou X, Maier C R, Patterson A D, Ding X, Dennis P A. A Cyp2a polymorphism predicts susceptibility to NNK-induced lung tumorigenesis in mice. Carcinogenesis. 2011, 32(8): 1279-1284.
  35. Zhang X, Li L, Ding X, Kaminsky L S. Identification of cytochrome P450 oxidoreductase gene variants that are significantly associated with the interindividual variations in warfarin maintenance dose. Drug Metab Dispos. 2011, 39(8): 1433-1439.
  36. Xie F, Zhou X, Genter M B, Behr M, Gu J, Ding X. The tissue-specific toxicity of methimazole in the mouse olfactory mucosa is partly mediated through target-tissue metabolic activation by CYP2A5. Drug Metab Dispos. 2011, 39(6): 947-951.
  37. Zhou X, Wei Y, Xie F, Laukaitis C M, Karn R C, Kluetzman K, Gu J, Zhang Q Y, Roberts D W, Ding X. A novel defensive mechanism against acetaminophen toxicity in the mouse lateral nasal gland: role of CYP2A5-mediated regulation of testosterone homeostasis and salivary androgen-binding protein expression. Mol Pharmacol. 2011, 79(4): 710-723.
  38. Hough L B, Nalwalk J W, Yang J, Conroy J L, VanAlstine M A, Yang W, Gargano J, Shan Z, Zhang S Z, Wentland M P, Phillips J G, Knapp B I, Bidlack J M, Zuiderveld O P, Leurs R, Ding X. Brain P450 epoxygenase activity is required for the antinociceptive effects of improgan, a nonopioid analgesic. Pain. 2011, 152(4): 878-887.
  39. Gonzalez M, Sealls W, Jesch E D, Brosnan M J, Ladunga I, Ding X, Black P N, DiRusso C C. Defining a relationship between dietary fatty acids and the cytochrome P450 system in a mouse model of fatty liver disease. Physiol Genomics. 2011, 43(3): 121-135.
  40. Cotten S W, Zou J, Valencia C A, Liu R. Selection of proteins with desired properties from natural proteome libraries using mRNA display. Nat Protoc. 2011, 6(8): 1163-1182.
  41. Wang H, Liu R. Advantages of mRNA display selections over other selection techniques for investigation of protein-protein interactions. Expert Rev Proteomics. 2011, 8(3): 335-346.
  42. Park K D, Kim D, Reamtong O, Eyers C, Gaskell S J, Liu R, Kohn H. Identification of a lacosamide binding protein using an affinity bait and chemical reporter strategy: 14-3-3 zeta. J Am Chem Soc. 2011, 133(29): 11320-11330.
  43. Yang J, Aguila J R, Alipio Z, Lai R, Fink L M, Ma Y. Enhanced self-renewal of hematopoietic stem/progenitor cells mediated by the stem cell gene Sall4. J Hematol Oncol. 2011, 4: 38.
  44. Aguila J R, Liao W, Yang J, Avila C, Hagag N, Senzel L, Ma Y. SALL4 is a robust stimulator for the expansion of hematopoietic stem cells. Blood. 2011, 118(3): 576-585.
  45. Gong Y, Li Y, Lu Y, Li L, Abdolmaleky H, Blackburn G L, Zhou J R. Bioactive tanshinones in Salvia miltiorrhiza inhibit the growth of prostate cancer cells in vitro and in mice. Int J Cancer. 2011, 129(5): 1042-1052.
  46. Zerbini L F, de Vasconcellos J F, Czibere A, Wang Y, Paccez J D, Gu X, Zhou J R, Libermann T A. JunD-mediated repression of GADD45alpha and gamma regulates escape from cell death in prostate cancer. Cell Cycle. 2011, 10(15): 2583-2591.
  47. Papageorgis P, Cheng K, Ozturk S, Gong Y, Lambert A W, Abdolmaleky H M, Zhou J R, Thiagalingam S. Smad4 inactivation promotes malignancy and drug resistance of colon cancer. Cancer Res. 2011, 71(3): 998-1008.
  48. Zerbini L F, Tamura R E, Correa R G, Czibere A, Cordeiro J, Bhasin M, Simabuco F M, Wang Y, Gu X, Li L, Sarkar D, Zhou J R, Fisher P B, Libermann T A. Combinatorial effect of non-steroidal anti-inflammatory drugs and NF-kappaB inhibitors in ovarian cancer therapy. PLoS One. 2011, 6(9): e24285.
  49. Liu X S, Zhao X D, Wang X, Yao Y X, Zhang L L, Shu R Z, Ren W H, Huang Y, Huang L, Gu M M, Kuang Y, Wang L, Lu S Y, Chi J, Fen J S, Wang Y F, Fei J, Dai W, Wang Z G. Germinal Cell Aplasia in Kif18a Mutant Male Mice Due to Impaired Chromosome Congression and Dysregulated BubR1 and CENP-E. Genes Cancer. 2010, 1(1): 26-39.
  50. Lu J, Wang L, Dai W, Lu L. Effect of hypoxic stress-activated Polo-like kinase 3 on corneal epithelial wound healing. Invest Ophthalmol Vis Sci. 2010, 51(10): 5034-5040.
  51. Xu D, Yao Y, Jiang X, Lu L, Dai W. Regulation of PTEN stability and activity by Plk3. J Biol Chem. 2010, 285(51): 39935-39942.
  52. Xu D, Yao Y, Lu L, Costa M, Dai W. Plk3 functions as an essential component of the hypoxia regulatory pathway by direct phosphorylation of HIF-1alpha. J Biol Chem. 2010, 285(50): 38944-38950.
  53. Zhou X, Zhuo X, Xie F, Kluetzman K, Shu Y Z, Humphreys W G, Ding X. Role of CYP2A5 in the clearance of nicotine and cotinine: insights from studies on a Cyp2a5-null mouse model. J Pharmacol Exp Ther. 2010, 332(2): 578-587.
  54. Conroy J L, Fang C, Gu J, Zeitlin S O, Yang W, Yang J, VanAlstine M A, Nalwalk J W, Albrecht P J, Mazurkiewicz J E, Snyder-Keller A, Shan Z, Zhang S Z, Wentland M P, Behr M, Knapp B I, Bidlack J M, Zuiderveld O P, Leurs R, Ding X, Hough L B. Opioids activate brain analgesic circuits through cytochrome P450/epoxygenase signaling. Nat Neurosci. 2010, 13(3): 284-286.
  55. Sheng L, Ding X, Ferguson M, McCallister M, Rhoades R, Maguire M, Ramesh A, Aschner M, Campbell D, Levitt P, Hood D B. Prenatal polycyclic aromatic hydrocarbon exposure leads to behavioral deficits and downregulation of receptor tyrosine kinase, MET. Toxicol Sci. 2010, 118(2): 625-634.
  56. Xie F, Zhou X, Behr M, Fang C, Horii Y, Gu J, Kannan K, Ding X. Mechanisms of olfactory toxicity of the herbicide 2,6-dichlorobenzonitrile: essential roles of CYP2A5 and target-tissue metabolic activation. Toxicol Appl Pharmacol. 2010, 249(1): 101-106.
  57. Weems J M, Lamb J G, D'Agostino J, Ding X, Yost G S. Potent mutagenicity of 3-methylindole requires pulmonary cytochrome P450-mediated bioactivation: a comparison to the prototype cigarette smoke mutagens B(a)P and NNK. Chem Res Toxicol. 2010, 23(11): 1682-1690.
  58. Wei Y, Zhou X, Fang C, Li L, Kluetzman K, Yang W, Zhang Q Y, Ding X. Generation of a mouse model with a reversible hypomorphic cytochrome P450 reductase gene: utility for tissue-specific rescue of the reductase expression, and insights from a resultant mouse model with global suppression of P450 reductase expression in extrahepatic tissues. J Pharmacol Exp Ther. 2010, 334(1): 69-77.
  59. Weng Y, Xie F, Xu L, Zagorevski D, Spink D C, Ding X. Analysis of testosterone and dihydrotestosterone in mouse tissues by liquid chromatography-electrospray ionization-tandem mass spectrometry. Anal Biochem. 2010, 402(2): 121-128.
  60. Park K D, Stables J P, Liu R, Kohn H. Proteomic searches comparing two (R)-lacosamide affinity baits: An electrophilic arylisothiocyanate and a photoactivated arylazide group. Org Biomol Chem. 2010, 8(12): 2803-2813.
  61. Alipio Z, Adcock D M, Waner M, O T M, Fink L M, Ward D C, Ma Y. Sustained factor VIII production in hemophiliac mice 1 year after engraftment with induced pluripotent stem cell-derived factor VIII producing endothelial cells. Blood Coagul Fibrinolysis. 2010, 21(5): 502-504.
  62. Alipio Z, Liao W, Roemer E J, Waner M, Fink L M, Ward D C, Ma Y. Reversal of hyperglycemia in diabetic mouse models using induced-pluripotent stem (iPS)-derived pancreatic beta-like cells. Proc Natl Acad Sci U S A. 2010, 107(30): 13426-13431.
  63. Gai H, Nguyen D M, Moon Y J, Aguila J R, Fink L M, Ward D C, Ma Y. Generation of murine hepatic lineage cells from induced pluripotent stem cells. Differentiation. 2010, 79(3): 171-181.
  64. Wang P, Wu F, Ma Y, Li L, Lai R, Young L C. Functional characterization of the kinase activation loop in nucleophosmin (NPM)-anaplastic lymphoma kinase (ALK) using tandem affinity purification and liquid chromatography-mass spectrometry. J Biol Chem. 2010, 285(1): 95-103.
  65. Yang J, Gao C, Chai L, Ma Y. A novel SALL4/OCT4 transcriptional feedback network for pluripotency of embryonic stem cells. PLoS One. 2010, 5(5): e10766.
  66. Li M, Jiang R, Hon P, Cheng L, Li L, Zhou J, Shaw P, But P P. Authentication of the anti-tumor herb Baihuasheshecao with bioactive marker compounds and molecular sequences. Food Chemistry. 2010, 119(3): 1239-1245.

 

Conference Abstract Publications:

  • Hanlu Wang, Meng Qin, et al. A Specific RNA Aptamer Targeting to and Inhibiting Non-Small Cell Lung Cancer. AACR Annual Meeting 2017. Poster presentation, Washington D.C, 2017
  • Zhenwang Jie, Yu Zhang, Chen Wang, Bin Shen, Xin Guan, Zhihua Ren, et al. Large-Scale Ex Vivo Generation of Human Neutrophils from Cord Blood CD34+ Cells. AACR Annual Meeting 2017. Poster presentation, Washington D.C, 2017
  • Xin Guan, Lan Wang, Yu Zhang, Bin Shen, Zhihua Ren, Yupo Ma, Wei Dai, Yongping Jiang. Pilot-Scale Production of Megakaryocytes/Platelets from Cord Blood CD34+ Cells in a Bottle Turning Device Culture System. 58th ASH Annual Meeting and Exposition. Oral presentation. San Diego, CA, 2016
  • Yu Zhang, Chen Wang, Lan Wang, Jing Tian, Bin Shen, Xin Guan, Zhihua Ren, Xinxin Ding, Yupo Ma, Wei Dai, Yongping Jiang. Ex vivo large-scaled generation of human red blood cells from cord blood CD34+ cells. 58th ASH Annual Meeting and Exposition. Oral presentation. San Diego, CA, 2016
  • Lan Wang, Xin Guan, Huihui Wang, Bin Shen, Yu Zhang, Zhihua Ren, Yupo Ma, Xinxin Ding and Yongping Jiang. Small Molecule Combination Enhances CD34+/CD38- Cell Proliferation via Inhibition of Differentiation. 58th ASH Annual Meeting and Exposition. Oral presentation. San Diego, CA, 2016
  • Hanlu Wang, Yibang Zhang, Chu Chang, et al: Identification of a Specific RNA Aptamer Targeting to Non-Small Cell Lung Cancer by In Vivo SELEX. AACR Annual Meeting 2016. Poster presentation, New Orleans, 2016
  • Hanlu Wang, Haiping Yang, et al: Evaluation of Efficacy of A RNA Aptamer toward Non-Small Cell Lung Cancer. AACR Annual Meeting 2016. Poster presentation, New Orleans, 2016
  • Yu Zhang, Bin Shen, Meng Qin, Zhihua Ren, Xinxin Ding, Yupo Ma, Wei Dai and Yongping Jiang. Functional Studies of ex vivo Expanded Hematopoietic Stem Cells in Mice and Monkeys. 57th ASH Annual Meeting and Exposition. Oral presentation. Orlando, FL, 2015
  • Xin Guan, Meng Qin, Yu Zhang, Zhihua Ren, Wenhong Jiang, Yupo Ma, Wei Dai and Yongping Jiang. Safety and Functional Studies of Ex Vivo Generated Megakaryocytic Progenitors/Platelets in a Myeloablative Non-Human Primate Model. 57th ASH Annual Meeting and Exposition. Oral presentation.Orlando, FL, 2015
  • Meng Qin, Xin Guan, Yu Zhang, Qingyu Zhang, Wei Dai, Yupo Ma and Yongping Jiang. Functional Evaluations of Ex Vivo Induced Endothelial Progenitors for Autologous Transplantation in Non-Human Primates. 57th ASH Annual Meeting and Exposition. Poster presentation. Orlando, FL, 2015
  • Xin Guan, Meng Qin, Bin Shen, Yu Zhang, Wenhong Jiang, Zhihua Ren, Yupo Ma, Wei Dai, Yongping Jiang. Ex Vivo Induction of Megakaryocytic Differentiation of Umbilical Cord Blood CD34+ Cells. 56th ASH Annual Meeting and Exposition. Oral presentation. San Francisco, CA, 2014.
  • Bin Shen, Wenhong Jiang, Jie Fan, Wei Dai, Xinxin Ding, YongpingJiang. A Structure-Function Study of the Activity of Stem Cell Factor in Stimulating the Expansion of Cord Blood CD34+ Cells. 56th ASH Annual Meeting and Exposition. Poster presentation.San Francisco, CA, 2014.
  • Yupo Ma, Wenbin Liao, Jerell R. Aguila, Yongping Jiang, Yixin Yao, Wei Dai. Expansion of Hematopoietic Stem Cells: Myths and Reality. The 1st pathological diagnosis forum of Hematological disease. Nov, 2012. Tianjin.
  • Jie Fan, Xinxin Ding, and Yongping Jiang. Characterization of a Novel Monoclonal Antibody to Human Stem Cell Factor and Determination of Its Effect on Ex Vivo Stem Cell Expansion. Cold Spring Harbor Asia. STEM CELLS & DEVELOPMENTAL MECHANISMS. Dec, 2012. Su Zhou.
  • Xia Fei, Jiang Yongping. Chronic toxicity study on a novel recombinant human granular-colony stimulating factor in rat. Novel Conception on systematic Tumor Diagnosis\Treatment. Dec, 2010. Sanya.
  • Xiao-Xiao Liu and Yong-Ping Jiang. Pharmacokinetic studies on a novel recombinant human granulocyte colony stimulating factor in rats. 100th Annual Meeting of American Association for Cancer Research. April 18-22, 2009. Colorado.CO.
  • Lixi Zhao and Yongping Jiang. Optimization of refolding and purification of recombiant human endostatin from E.coli. 100th Annual Meeting of American Association for Cancer Research. April 18-22, 2009. Colorado.CO.
  • Jie Fan, Xin-Xin Ding, Yong-Ping Jiang. Toxicologic studies on a novel recombinant human granulocyte colony stimulating factor. The Society of Chinese Bioscientists in America Thirteenth Symposium. July 25-29, 2009. Guangzhou.
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